منابع مشابه
Architecture of viral replication factories
Compartmentalization of intracellular membrane is a marked characteristic during the pathogenesis of many viruses, which provides a microenvironment for virus to evade the host RNA interference defense response on one hand, and confines various host factors as well as metabolites in a stable space so that they can act in concert to complete virus replication cycle [1]. Recently, advanced imagin...
متن کاملCoronavirus Genome Replication
Viruses belonging to the family Coronaviridae are unique among RNA viruses because of the unusually large size of their genome, which is of messengeror positiveor plus-sense. It is ∼30,000 bases or 2–3 times larger than the genomes of most other RNA viruses. Coronaviruses belong to the order Nidovirales, the other three families being the Arteriviridae, Toroviridae and Roniviridae. (For a revie...
متن کاملBiochemical aspects of coronavirus replication.
infected cells. Nevertheless, there is a limited knowledge of the biochemical events occurring in host cells and in the biochemistry of the infection. Infections by CoVs cause alterations in host cells in transcription and translation patterns, in the cell cycle, in the cytoskeleton, and in apoptosis pathways. In addition, in the host, CoV infection may cause inflammation, alterations of the im...
متن کاملUltrastructural Characterization of Zika Virus Replication Factories
A global concern has emerged with the pandemic spread of Zika virus (ZIKV) infections that can cause severe neurological symptoms in adults and newborns. ZIKV is a positive-strand RNA virus replicating in virus-induced membranous replication factories (RFs). Here we used various imaging techniques to investigate the ultrastructural details of ZIKV RFs and their relationship with host cell organ...
متن کاملDynamics of coronavirus replication-transcription complexes.
Coronaviruses induce in infected cells the formation of double-membrane vesicles (DMVs) in which the replication-transcription complexes (RTCs) are anchored. To study the dynamics of these coronavirus replicative structures, we generated recombinant murine hepatitis coronaviruses that express tagged versions of the nonstructural protein nsp2. We demonstrated by using immunofluorescence assays a...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2020
ISSN: 1740-1526,1740-1534
DOI: 10.1038/s41579-020-0406-z